Associate Professor
Dr. Zobaer Al Mahmud
Department of Clinical Pharmacy and Pharmacology
Faculty of Pharmacy
Research profiles & links
Social
Biography
I am an Associate Professor in the Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Bangladesh. I completed my PhD at the University of Glasgow, UK, where I investigated GPR84 pharmacology in Prof. Graeme Milligan’s laboratory. My research focuses on GPCR pharmacology, immunometabolism, and drug discovery, with particular interest in orphan GPCRs, allosteric modulation, ligand-directed signalling, ...
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| Degree Name | Group/Major Subject | Board/Institute | Country | Passing Year |
|---|---|---|---|---|
| Ph.D. | Molecular Pharmacology | University of Glasgow | United Kingdom | 2019 |
| Masters | Clinical Pharmacy and Pharmacology | University of Dhaka | Bangladesh | 2008 |
| Bachelor | Pharmacy | University of Dhaka | Bangladesh | 2007 |
| Title | Organization | Location | From Date | To Date | |
|---|---|---|---|---|---|
| No experience is found | |||||
Research Interest
| Subject | Description | Research Interest (Goal, Target Indicator) |
|---|---|---|
| GPCR Pharmacology | My research on GPCR pharmacology includes defining the role of G protein-coupled receptor 84 (GPR84) signalling in pathophysiology of several metablic/inflammatory disorders including osteoarthritis, diabetes mellitus, NAFLD and hepatic fibrosis using a range of animal disease models. We are also investigating the in-vivo characterization of novel small molecule drug candidates targeting this receptor. |
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| Pharmacogenomics | Currently I am evaluating the effect of genetic variations in genes encoding GPCRs, VEGF, VEGFRs, cytokines and chemokines on disease risk/susceptibility in Bangladeshi demographics. Major objectives of these genetic studies is to find out novel and effective genetic/vascular/immunological blood-based biomarker(s) for the hard to diagnose diseases. |
Project/Research Supervision
| Level of Study | Title | Supervisor | Co-Supervisor(s) | Name of Student(s) | Area of Research | Current Completion |
|---|---|---|---|---|---|---|
| No project/research supervision is found | ||||||
Project/Research Work
| Subject | Project Name | Source of Fund | From Date | To Date | Collaboration |
|---|---|---|---|---|---|
| GPCR pharmacology ( In vivo) | In-vivo animal model studies characterizing the role of GPR84 in pathogenesis of Type II diabetes mellitus, hepatic fibrosis and osteoarthritis: | 01-02-2024 |
Invited Talk
| SL | Invited Talk |
|---|---|
| No invited talk is found | |
| SL | Collaboration & Membership Name | Type | Membership Year | Expire Year |
|---|---|---|---|---|
| No Collaboration & Membership is found | ||||
| Journal Article | |
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| 1 |
Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Jingkai Zhou, Fabian Gossen, Pinqi Wang, Zobaer Al Mahmud, Yueming Li, Andhika B. Mahardhika, Christa E. Müller, Mingye Feng, Angela J. Russell, Irina G. Tikhonova, Graeme Milligan and Cheng Zhang : Mechanism of GPR84 allosteric modulation at a helix 8–proximate site,
Science Advances (impact factor:13.9) , vol.12 , no.13 AAAS , pp.15 , 2026
.
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| 2 |
Mamun-or-Rashid, A. S. M. Roknuzzaman, Rapty Sarker, Jannatul Nayem, Mohiuddin Ahmed Bhuiyan, Md. Rabiul Islam and Zobaer Al Mahmud : Altered serum interleukin-17A and interleukin-23A levels may be associated with the pathophysiology and development of generalized anxiety disorder,
Scientific Reports (impact factor:4.9) , vol.14(1) , no.Article number 15097 (2024) Nature Portfolio , pp.11 , 2024
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| 3 |
Nisat Sarmin, A. S. M. Roknuzzaman, Rapty Sarker, Mamun -or-Rashid, MMA Shalahuddin Qusar, Sitesh Chandra Bachar, Eva Rahman Kabir, Md. Rabiul Islam and Zobaer Al Mahmud : Association of interleukin-2 and interleukin-10 with the pathophysiology and development of generalized anxiety disorder: a case-control study,
BMC Psychiatry (impact factor:4.6) , vol.24(1) , no.Article number 462 (2024) Springer Nature , pp.12 , 2024
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| 4 |
Nisat Sarmin, A. S. M. Roknuzzaman, Rapty Sarker, Mamun-or- Rashid, Ahasanul Hasan, M. M. A. Shalahuddin Qusar, Eva Rahman Kabir, Md. Rabiul Islam and Zobaer Al Mahmud : Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder,
PLOS One (impact factor:2.8) , vol.19 , no.6 Public Library of Science , pp.15 , 2024
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| 5 |
Nisat Sarmin, A. S. M. Roknuzzaman, Tashfiya Zaman Mouree, Md. Rabiul Islam and Zobaer Al Mahmud : Evaluation of serum interleukin-12 and interleukin-4 as potential biomarkers for the diagnosis of major depressive disorder,
Scientific Reports (impact factor:4.9) , vol.14 , no.Article number 1652, (2024) Nature Portfolio , pp.11 , 2024
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| 6 |
Jannatul Nayem, Rapty Sarker, A S M Roknuzzaman, M M A Shalahuddin Qusar, Sheikh Zahir Raihan, Md Rabiul Islam and Zobaer Al Mahmud : Altered serum TNF-α and MCP-4 levels are associated with the pathophysiology of major depressive disorder: A case-control study results,
PLoS One (impact factor:3.72 (2022)) , vol.18 , no.(11):e0294288 PLOS , pp.17 , 2023
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| 7 |
Sara Marsango, Richard J. Ward, Laura Jenkins, Adrian J. Butcher, Zobaer Al Mahmud, Louis Dwomoh, Falko Nagel, Stefan Schulz, Irina G. Tikhonova, Andrew B. Tobin and Graeme Milligan : Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands,
Journal of Biological Chemistry (impact factor:5.485) , vol.298 , no.5:101932 American Society for Biochemistry and Molecular Biology , pp.15 , 2022
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| 8 |
Laura Jenkins, Sara Marsango, Sarah Mancini, Zobaer Al Mahmud, Angus Morrison, Stuart P. McElroy, Kirstie A. Bennett, Matt Barnes, Andrew B. Tobin, Irina G. Tikhonova and Graeme Milligan : Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84,
ACS Pharmacology and Translational Science (impact factor:6 (2022)) , vol.4 , no.5 American Chemical Society , pp.1598–1613 , 2021
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| 9 |
Sarah J. Mancini, Zobaer Al Mahmud, Laura Jenkins, Daniele Bolognini, Robert Newman, Matt Barnes, Michelle E. Edye, Stephen B. McMahon, Andrew B. Tobin and Graeme Milligan : On-target and off-target effects of novel orthosteric and allosteric activators of GPR84,
Scientific Reports (impact factor:4.9) , vol.9 , no.Article number 1861 (2019) Nature Portfolio , pp.15 , 2019
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| 10 |
Zobaer Al Mahmud, Laura Jenkins, Trond Ulven, Frédéric Labéguère, Romain Gosmini, Steve De Vos, Brian D. Hudson, Irina G. Tikhonova and Graeme Milligan : Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84,
Scientific Reports (impact factor:4.9) , vol.7 , no.Article number: 17953 (2017) Nature Portfolio , pp.15 , 2017
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| 11 |
Amlan Ganguly, Zobaer Al Mahmud, Sajal Kumar Saha and S M Abdur Rahman : Evaluation of antinociceptive and antidiarrhoeal properties of Manilkara zapota leaves in Swiss albino mice,
Pharmaceutical Biology (impact factor:3.8 (2022)) , vol.54 , no.8 Taylor & Francis , pp.1413-9 , 2016
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| Award Type | Title | Year | Country | Description |
|---|---|---|---|---|
| International | Commonwealth PhD Scholarship in UK | 2015 | United Kingdom | |
| Local | Writer Sarder Joyen-Uddin Gold Medal | 2009 | Bangladesh | |
| Local | ACI Abdul Mukit Gold Medal | 2008 | Bangladesh | |
| Local | Deans Award | 2008 | Bangladesh |
Name & designation
Dr. Zobaer Al Mahmud
Associate Professor
Department
Department of Clinical Pharmacy and Pharmacology Faculty of Pharmacy
Email
zalmahmud@du.ac.bd
Phone
+88-01301596950